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As we age, the underlying tissues that keep our skin looking youthful and plump begin to break down, often leaving laugh lines, smile lines, crow’s feet or facial creases. Soft-tissue fillers, most commonly injectable collagen or fat from other parts of your body (also called fat transfer), can help fill in these lines and creases, temporarily restoring a smoother, more youthful-looking appearance. They can also add fullness to the lips and cheeks.